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Toxin-coregulated pilus

WebThe Vibrio cholerae toxin-coregulated pilus (TCP) and the enterotoxigenic Escherichia coli CFA/III pilus each mediates export of a single ... Toxin cargo genes are often horizontally transferred by phages between bacterial species and are known to play an important role in the evolution of bacterial pathogenesis. Here, we show how these same ... WebApr 5, 2024 · The host receptor for the CTXφ phage is the toxin-coregulated (TCP) type IV bundle-forming pilus, which itself is an important virulence factor. ... Mekalanos JJ (2003) Examination of diverse toxin-coregulated pilus-positive Vibrio cholerae strains fails to demonstrate evidence for Vibrio pathogenicity island phage. Infect Immun 71: 2993 ...

CTXφ bacteriophage - Wikipedia

Webtoxin coregulated pilus biosynthesis protein H toxin coregulated pilus biosynthesis protein T vpsU tyrosine-protein phosphatase vpsA vc0918 vpsB vpsC serine O-acetyltransferase rbmA rbmC vpsL znuA zinc transport system substrate-binding protein znuC zinc transport system ATP-binding protein znuB zinc transport system permease protein prsA WebFeb 19, 2002 · We focused on the regulators LuxO and HapR because homologues of these two proteins control quorum sensing in the closely related luminous marine bacterium … google oauth api url https://joxleydb.com

Filamentous phages: masters of a microbial sharing economy

WebJan 1, 2008 · Vibrio cholerae toxin-coregulated pili (TCP) are Type IV pili that self-aggregate, bringing the bacteria together in microcolonies that protect them from host defenses and … WebApr 13, 2024 · Cholera is a rapidly dehydrating diarrheal disease caused by a toxin-producing bacteria, Vibrio cholerae. The etiologic agent and pathogenesis of infection with toxigenic V. choleraeis reviewed here. The clinical approach to patients with cholera is discussed separately. (See "Cholera: Clinical features, diagnosis, treatment, and prevention".) WebFeb 19, 2002 · Two factors are critical to V. cholerae virulence—cholera enterotoxin (CT) and an intestinal colonization factor known as the toxin-coregulated pilus (TCP). Poorly characterized environmental cues influence the expression of CT and TCP in vivo ( 2 ). chicken and cone san antonio

The Toxin-Coregulated Pilus: Biogenesis and Function

Category:National Center for Biotechnology Information

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Toxin-coregulated pilus

National Center for Biotechnology Information

Web毒素共调菌毛(Toxin-coregulated pilus, TCP) 其他：鞭毛、溶血素、RTX外毒素、神经氨酸酶、外膜蛋白. 世界各地霍乱菌株耐药的情况比较复杂，抗生素的种类差别很大. 七十年代 :大多数菌株对用于腹泻性疾病治疗的抗生素是敏感的 WebApr 9, 2015 · Strains isolated by conventional culture were mostly (99.2%) negative for the major virulence gene clusters encoding toxin …

Toxin-coregulated pilus

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WebNational Center for Biotechnology Information WebFor example, the major toxin-coregulated pilus (TCP) gene, tcpA, of the TCP cluster possesses classical- and El Tor-specific alleles that encode identical functions but differ …

WebNov 17, 2024 · The surface-exposed pilus filament is a multimeric helical structure that is primarily composed of a single repeating subunit called the major pilin. This filament is … WebThe toxin-coregulated pilus (TCP) of Vibrio cholerae: molecular cloning of genes involved in pilus biosynthesis and evaluation of TCP as a protective antigen in the infant mouse …

WebJan 8, 2008 · The bacterial pathogen Vibrio cholerae uses toxin-coregulated pili (TCP) to colonize the human intestine, causing the severe diarrheal disease cholera. TCP are long, … WebApr 14, 2015 · Toxin-coregulating pilus (TCP) is the pilin for V. cholerae, considered very important for its virulence. [12] Structure TCP is classified as a type IVb pilin (i.e. it is present on bacteria that colonize the human …

WebMar 19, 2024 · 2.5.1 The toxin coregulated pilus. The pandemic virulence potential of V. cholerae resides in its MGE, harbouring both the CT and TCP apparel on the integrated CTXφ phage and Vibrio Pathogenic Island 1 (VPI-1), respectively . TCP is essential for effective colonization of the intestinal epithelium in pandemic O1/O139 strains .

WebFor example, the major toxin-coregulated pilus (TCP) gene, tcpA, of the TCP cluster possesses classical- and El Tor-specific alleles that encode identical functions but differ … chicken and corn chowder healthyWebOct 14, 2024 · “It was known that the Toxin-coregulated pilus (TCP), a type 4 pilus system, played a crucial role in TcpF secretion, but the exact interaction between the two was unclear” states Hiroya Oki,... google oauth bearer tokenWebMethods: Vibrio cholerae isolates collected from the Pearl River estuary waters from January 2009 to December 2010, were tested by PCR for eight virulence-related genes, including cholera toxin (ctxA), zonula occludens toxin (zot), accessory cholera enterotoxin (ace), hemolysin (hlyA), toxin-coregulated pilus (tcpA), outer membrane protein ... google oauth app verificationWebDec 1, 1989 · The toxin-coregulated pilus (TCP) of Vibrio cholerae: molecular cloning of genes involved in pilus biosynthesis and evaluation of TCP as a protective antigen in the … google oauth app redirect urlsWebDec 19, 2016 · TCP are members of the Type IV pilus (T4P) class, which are expressed by many Gram-negative bacteria as well as some Gram-positive species and archaea [ 12 – … google oauth client library for javaWebJan 20, 1998 · ToxR is an inner membrane protein that contains a cytoplasmic DNA-binding domain with homology to the OmpR subfamily of the regulator proteins of the two-component signal transduction family (6). The periplasmic domain of ToxR is thought to interact with another transmembrane regulatory protein, ToxS, that stimulates its activity … google oauth dashboardWebOct 10, 2012 · Type IV pili are long thin surface-displayed polymers of the pilin subunit that are present in a diverse group of bacteria. These multifunctional filaments are critical to virulence for pathogens such as Vibrio cholerae, which use them to form microcolonies and to secrete the colonization factor TcpF ... Macromolecules Find similar proteins by: google oauth clientid