WebThese compounds are derivatives of sulfonic acid, thiosulfonic acid, and phosphonic acid in which S may substitute for O and organic groups may substitute for H. These compounds … WebSep 21, 2024 · Phosphonate noun. (chemistry) Any salt or ester of a phosphonic acid; many of its derivatives have important biological activity. Phosphate noun. (chemistry) Any salt …
Organic Phosphate - an overview ScienceDirect Topics
WebSep 21, 2024 · The second step is the substitution reaction of P-chirogenic compounds with a hydroxybinaphthyl group with lithium alkoxides, leading to the formation of P-chirogenic phosphates and phosphonates ... WebPhosphonates, phosphinates, and phosphates are prominently represented as pharmacophores in various classes of biological agents. These include antiviral and … thailande basse saison
Prodrugs of Phosphonates and Phosphates: Crossing the
WebSpecial consideration is given to the approaches towards the preparing of the phosphoramidites and monoesters of phosphoric acid (H-phosphonate monoesters), the procedures of the activation and condensation of these initial monomers with nucleofiles, the means of the oxidation of phosphites to phosphates and the ways for the synthesis of … WebThe phosphonategroup enables it to mimic a nucleotide and bypass virus-dependent phosphorylation. Cellular enzymes convert it to the triphosphate, which has in-vitro and in-vivo activity against CMV and other herpesviruses, including aciclovir-resistant HSV. Oral hairy leukoplakia resolved on therapy, suggesting that it has activity against EBV. WebPhosphonates, often used as isosteric replacements for phosphates, can provide important interactions with an enzyme. Due to their high charge at physiological pH, however, permeation into cells can be a challenge. Protecting phosphonates as prodrugs has shown promise in drug delivery. thailand ebird