SpletAims. To investigate the association between plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations, current acute coronary syndrome (ACS), coronary artery disease (CAD) presence, severity and extension and the burden of coronary calcifications in patients with suspected CAD. Splet14. maj 2024 · PCSK9 from plasma and vascular cells can contribute to the development of atherosclerotic plaque and thrombosis by promoting platelet activation, leukocyte …
A single injection of gain-of-function mutant PCSK9
Splet09. jun. 2024 · Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes LDLR degradation, increasing plasma LDL-C levels. Circulating PCSK9 is mainly secreted by the liver, whereas VLDL is exclusively secreted by hepatocytes. However, the mechanism regulating their secretion is not completely understood. SpletConclusion: AAV-mediated infection with a mouse PCSK9 gain-of-function mutation is a rapid, easy, and efficient approach for inducing hypercholesterolemia and promoting … headgear splatoon
Hypercholesterolemia Induced by a PCSK9 Gain-of-Function …
SpletAAV-PCSK9 led to elevated serum PCSK9, hypercholesterolemia, and rapid atherosclerosis development within 3 weeks as determined by gross plaque imaging, and staining with Oil-Red-O, Movat’s pentachrome and CD45 antibody. These plaque lesions were comparable to the atherosclerotic lesions that have been previously observed in Splet24. sep. 2024 · These results indicated that AAV-PCSK9 injection could successfully trigger atherosclerosis plaque formation in db/db mice after feeding a high-cholesterol diet within 8 weeks. This model is also suitable for assessing plaque composition. Download : Download high-res image (1MB) Download : Download full-size image Fig. 2. SpletDownload scientific diagram AAV8-PCSK9-3′-UTR alleviates hyperlipidemia and atherosclerosis. (A-E) Male and female C57BL/6 mice were administered a single dose of AAV8-PCSK9 (w/o 3′-UTR) or ... headgear stories