The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus. The glomerular endothelial cells, the glomerular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule. The glomerular basement membrane is a fusion of the endothelial cell and podocyte basal laminas, and is the main site of restriction of water flo… WebJan 19, 2024 · The glomeruli are the filtering units of the kidney, where blood gets filtered under pressure through the GBM into another space, called Bowman’s space, as urine. About 1-2 million glomeruli in each kidney do the filtering, creating a filtrate of water, sodium, potassium, chloride, glucose and small proteins.
Anti-glomerular basement membrane nephritis: why we still …
WebAnti-glomerular basement membrane (GBM) antibody disease is an autoimmune glomerulonephritis and accounts for up to 10% of RPGN cases. It may arise when respiratory exposures (eg, cigarette smoke, … WebAnti-glomerular basement membrane glomerulonephritis (anti-GBM nephritis) is a severe acute kidney disease characterized by a variety of lesion patterns, including crescents, vascular loop necrosis, and mesangial expansion, suggesting multiple pathogenic mechanisms [1,2,3,4].The upstream role of the adaptive immune system in failing to … armansyah ginting
AJKD Atlas of Renal Pathology: Anti–Glomerular …
WebMay 21, 2024 · The kidney biopsy demonstrated no significant pathology aside from diffuse thinning of the GBM. Furthermore, during the 12-month follow-up, there were no episodes of hemoptysis or renal impairment. Considering both previous case reports and the clinical course of this patient, it is likely that patients with concurrent anti-GBM disease and … WebOct 11, 2024 · Treatment. Prognosis. Goodpasture syndrome is a very rare and potentially life-threatening autoimmune disease that damages both the lungs and the kidneys. 1 It is … WebThe glomerular basement membrane (GBM) 1 of the kidney is an essential component of the blood filtration barrier. The GBM function is impaired in certain renal diseases, including Alport syndrome, a hereditary form of … arman syah putra