WebJan 4, 2024 · “On the surface it seemed like a simple task. In our case it turned out quite challenging,” Shapiro said. Gas vesicles are built by 11 different genes, some of which produce proteins that make ... WebMay 1, 2024 · Gas vesicles (GVs) are a unique class of biologically derived, gas-filled protein nanostructures recently described as a new type of ultrasound contrast agent (UCA) (Shapiro et al. 2014). GVs are formed by certain species of Archaea and Bacteria as a means to regulate cellular buoyancy. They are made principally of a small protein (GvpA ...

Acoustic Behavior of Halobacterium salinarum Gas Vesicles in …

WebJan 6, 2016 · Gas vesicles have potential applications in multiple fields, including in nanoparticles (DasSarma et al., 2014), as a contrast agent in ultrasound imaging (Shapiro et al., 2014a,b), and for delivery of antigens as fusion proteins (DasSarma et … WebEngineering of gas vesicles as ultrasound-responsive, genetically encodable protein bubbles. 19th April 2024 Timing : 1 pm EST . ... George Lu obtained his Ph.D. in protein biochemistry at UC San Diego before joining the lab of Mikhail Shapiro at Caltech for his postdoctoral training. There, he focused on the engineering of gas-filled protein ... git show branch list

Engineered Bacteria Use Air Bubbles as ... - Scientific American

WebAug 27, 2024 · However, most of the optical (e.g., nanoparticles, dyes) and acoustic (e.g., gas vesicles) imaging probes have limitations of fast clearance and low specificity in the tumors . In the near future, a non-invasive microbe imaging probe may be achieved by genetically engineering the bacteria with different reporter genes to enable the ... WebApr 23, 2024 · Realizing that only intact gas vesicles induce imaging contrast, Shapiro and colleagues addressed these issues by applying … WebCaltech chemical engineer Mikhail Shapiro has shown hidden potential of gas vesicles. git show branch tree graph